Ontology highlight
ABSTRACT:
SUBMITTER: Wapner RJ
PROVIDER: S-EPMC3549418 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Wapner Ronald J RJ Martin Christa Lese CL Levy Brynn B Ballif Blake C BC Eng Christine M CM Zachary Julia M JM Savage Melissa M Platt Lawrence D LD Saltzman Daniel D Grobman William A WA Klugman Susan S Scholl Thomas T Simpson Joe Leigh JL McCall Kimberly K Aggarwal Vimla S VS Bunke Brian B Nahum Odelia O Patel Ankita A Lamb Allen N AN Thom Elizabeth A EA Beaudet Arthur L AL Ledbetter David H DH Shaffer Lisa G LG Jackson Laird L
The New England journal of medicine 20121201 23
<h4>Background</h4>Chromosomal microarray analysis has emerged as a primary diagnostic tool for the evaluation of developmental delay and structural malformations in children. We aimed to evaluate the accuracy, efficacy, and incremental yield of chromosomal microarray analysis as compared with karyotyping for routine prenatal diagnosis.<h4>Methods</h4>Samples from women undergoing prenatal diagnosis at 29 centers were sent to a central karyotyping laboratory. Each sample was split in two; standa ...[more]