Ontology highlight
ABSTRACT:
SUBMITTER: Teirlinck AC
PROVIDER: S-EPMC3549599 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20121127 4
<h4>Unlabelled</h4>We established a new field clone of Plasmodium falciparum for use in controlled human malaria infections and vaccine studies to complement the current small portfolio of P. falciparum strains, primarily based on NF54. The Cambodian clone NF135.C10 consistently produced gametocytes and generated substantial numbers of sporozoites in Anopheles mosquitoes and diverged from NF54 parasites by genetic markers. In a controlled human malaria infection trial, 3 of 5 volunteers challeng ...[more]