Ontology highlight
ABSTRACT:
SUBMITTER: Hurley A
PROVIDER: S-EPMC3549602 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Hurley Amanda A Smith Mindy M Karpova Tatiana T Hasley Rebecca B RB Belkina Natalya N Shaw Stephen S Balenga Nariman N Druey Kirk M KM Nickel Erin E Packard Beverly B Imamichi Hiromi H Hu Zonghui Z Follmann Dean D McNally James J Higgins Jeanette J Sneller Michael M Lane H Clifford HC Catalfamo Marta M
The Journal of infectious diseases 20121129 4
Disruption of vascular integrity by trauma and other tissue insults leads to inflammation and activation of the coagulation cascade. The serine protease thrombin links these 2 processes. The proinflammatory function of thrombin is mediated by activation of protease-activated receptor 1 (PAR-1). We found that peripheral blood effector memory CD4(+) and CD8(+) T lymphocytes expressed PAR-1 and that expression was increased in CD8(+) T cells from human immunodeficiency virus (HIV)-infected patients ...[more]