Ontology highlight
ABSTRACT:
SUBMITTER: Tong H
PROVIDER: S-EPMC3549606 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Tong Huimin H Zhang Lei L Kaspar Allan A Rames Matthew J MJ Huang Liqing L Woodnutt Gary G Ren Gang G
Scientific reports 20130121
Peptides show much promise as potent and selective drug candidates. Fusing peptides to a scaffold monoclonal antibody produces a conjugated antibody which has the advantages of peptide activity yet also has the pharmacokinetics determined by the scaffold antibody. However, the conjugated antibody often has poor binding affinity to antigens that may be related to unknown structural changes. The study of the conformational change is difficult by conventional techniques because structural fluctuati ...[more]