Ontology highlight
ABSTRACT:
SUBMITTER: Heidel FH
PROVIDER: S-EPMC3549713 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Heidel Florian H FH Bullinger Lars L Arreba-Tutusaus Patricia P Wang Zhu Z Gaebel Julia J Hirt Carsten C Niederwieser Dietger D Lane Steven W SW Döhner Konstanze K Vasioukhin Valera V Fischer Thomas T Armstrong Scott A SA
The Journal of experimental medicine 20121231 1
A unique characteristic of hematopoietic stem cells (HSCs) is the ability to self-renew. Several genes and signaling pathways control the fine balance between self-renewal and differentiation in HSCs and potentially also in leukemia stem cells. Recently, studies have shed light on developmental molecules and evolutionarily conserved signals as regulators of stem cells in hematopoiesis and leukemia. In this study, we provide evidence that the cell fate determinant Llgl1 (lethal giant larvae homol ...[more]