Ontology highlight
ABSTRACT:
SUBMITTER: Jeong YT
PROVIDER: S-EPMC3549964 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Jeong Yeon-Tae YT Rossi Mario M Cermak Lukas L Saraf Anita A Florens Laurence L Washburn Michael P MP Sung Patrick P Schildkraut Carl L CL Pagano Michele M
The Journal of cell biology 20130114 2
Proper resolution of stalled replication forks is essential for genome stability. Purification of FBH1, a UvrD DNA helicase, identified a physical interaction with replication protein A (RPA), the major cellular single-stranded DNA (ssDNA)-binding protein complex. Compared with control cells, FBH1-depleted cells responded to replication stress with considerably fewer double-strand breaks (DSBs), a dramatic reduction in the activation of ATM and DNA-PK and phosphorylation of RPA2 and p53, and a s ...[more]