Ontology highlight
ABSTRACT:
SUBMITTER: Tsai A
PROVIDER: S-EPMC3551403 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Tsai Alex A Huang Chu-Chung CC Yang Albert C AC Liu Mu-En ME Tu Pei-Chi PC Hong Chen-Jee CJ Liou Ying-Jay YJ Chen Jin-Fan JF Lin Ching-Po CP Tsai Shih-Jen SJ
Dementia and geriatric cognitive disorders extra 20120101 1
<h4>Aims</h4>β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is a biological and positional candidate gene for Alzheimer's disease (AD). Previous studies found that BACE1-null mice had impaired performance on cognition and neurodegeneration during the aging process. Additionally, a synonymous polymorphism of BACE1 (rs638405) in exon 5 has been reported to be associated with risk for AD. We hypothesized that this BACE1 gene variant might influence regional brain volumes and cogni ...[more]