Ontology highlight
ABSTRACT:
SUBMITTER: Mullen DG
PROVIDER: S-EPMC3551542 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Mullen Daniel G DG Verardi Raffaello R Porcelli Fernando F Scaloni Andrea A Barany George G Veglia Gianluigi G
Biopolymers 20120101 5
Distinctin, a 47-residue heterodimeric peptide with potent antimicrobial activity, comprises two monomeric units linked covalently by a disulfide bond between Cys19 from the 22-residue A chain and Cys23 from the 25-residue B chain. Previous synthetic strategies involved assemblies of the two individual chains, followed by their co-oxidation to form the connecting disulfide bridge, and resulted in a mixture of three species: two homodimers and one heterodimer. Here, we report synthesis of exclusi ...[more]