Topological variation in the evolution of new reactions in functionally diverse enzyme superfamilies.
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ABSTRACT:
SUBMITTER: Meng EC
PROVIDER: S-EPMC3551608 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Topological variation in the evolution of new reactions in functionally diverse enzyme superfamilies.
Meng Elaine C EC Babbitt Patricia C PC
Current opinion in structural biology 20110401 3
In functionally diverse enzyme superfamilies (SFs), conserved structural and active site features reflect catalytic capabilities 'hard-wired' in each SF architecture. Overlaid on this foundation, evolutionary changes in active site machinery, structural topology and other aspects of structural organization and interactions support the emergence of new reactions, mechanisms, and substrate specificity. This review connects topological with functional variation in each of the haloalkanoic acid deha ...[more]
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