A kinetic-based model of radiation-induced intercellular signalling.
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ABSTRACT:
SUBMITTER: McMahon SJ
PROVIDER: S-EPMC3551852 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
A kinetic-based model of radiation-induced intercellular signalling.
McMahon Stephen J SJ Butterworth Karl T KT Trainor Colman C McGarry Conor K CK O'Sullivan Joe M JM Schettino Giuseppe G Hounsell Alan R AR Prise Kevin M KM
PloS one 20130122 1
It is now widely accepted that intercellular communication can cause significant variations in cellular responses to genotoxic stress. The radiation-induced bystander effect is a prime example of this effect, where cells shielded from radiation exposure see a significant reduction in survival when cultured with irradiated cells. However, there is a lack of robust, quantitative models of this effect which are widely applicable. In this work, we present a novel mathematical model of radiation-indu ...[more]
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