Unknown

Dataset Information

0

TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults.


ABSTRACT: HIV-patients have excess of pneumococcal infection. We immunized 40 HIV-patients twice with pneumococcal conjugate vaccine (Prevnar, Pfizer) +/- a TLR9 agonist (CPG 7909). Peripheral blood mononuclear cells were stimulated with pneumococcal polysaccharides and cytokine concentrations measured. The CPG 7909 adjuvant group had significantly higher relative cytokine responses than the placebo group for IL-1?, IL-2R, IL-6, IFN-? and MIP-?, which, did not correlate with IgG antibody responses. These findings suggests that CPG 7909 as adjuvant to pneumococcal conjugate vaccine induces cellular memory to pneumococcal polysaccharides in HIV-patients, independently of the humoral response.

SUBMITTER: Offersen R 

PROVIDER: S-EPMC3551874 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults.

Offersen Rasmus R   Melchjorsen Jesper J   Paludan Søren R SR   Østergaard Lars L   Tolstrup Martin M   Søgaard Ole S OS  

Human vaccines & immunotherapeutics 20120801 8


HIV-patients have excess of pneumococcal infection. We immunized 40 HIV-patients twice with pneumococcal conjugate vaccine (Prevnar, Pfizer) +/- a TLR9 agonist (CPG 7909). Peripheral blood mononuclear cells were stimulated with pneumococcal polysaccharides and cytokine concentrations measured. The CPG 7909 adjuvant group had significantly higher relative cytokine responses than the placebo group for IL-1β, IL-2R, IL-6, IFN-γ and MIP-β, which, did not correlate with IgG antibody responses. These  ...[more]

Shared Molecules

Only show the datasets with similarity scores above: 0.5
     

Similar Datasets

| S-EPMC2634740 | biostudies-literature
| S-EPMC3166350 | biostudies-literature
| S-EPMC4663990 | biostudies-literature
| S-EPMC2873559 | biostudies-literature
| S-EPMC6016414 | biostudies-other
| S-EPMC3825555 | biostudies-literature
| S-EPMC4521829 | biostudies-literature
| S-EPMC5848315 | biostudies-literature
| S-EPMC2932785 | biostudies-literature
| S-EPMC3419246 | biostudies-literature