Ontology highlight
ABSTRACT:
SUBMITTER: Offersen R
PROVIDER: S-EPMC3551874 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Offersen Rasmus R Melchjorsen Jesper J Paludan Søren R SR Østergaard Lars L Tolstrup Martin M Søgaard Ole S OS
Human vaccines & immunotherapeutics 20120801 8
HIV-patients have excess of pneumococcal infection. We immunized 40 HIV-patients twice with pneumococcal conjugate vaccine (Prevnar, Pfizer) +/- a TLR9 agonist (CPG 7909). Peripheral blood mononuclear cells were stimulated with pneumococcal polysaccharides and cytokine concentrations measured. The CPG 7909 adjuvant group had significantly higher relative cytokine responses than the placebo group for IL-1β, IL-2R, IL-6, IFN-γ and MIP-β, which, did not correlate with IgG antibody responses. These ...[more]