Ontology highlight
ABSTRACT:
SUBMITTER: Huang K
PROVIDER: S-EPMC3552254 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Biophysical journal 20130101 2
The molecular mechanism and energetics of the translocation of arginine-rich, cell-penetrating peptides through membranes are still under debate. One possible mechanism involves the formation of a water pore in the membrane such that the hydrophilic residues of the peptide are solvated throughout the translocating process. In this work, employing two different order parameters, we calculate the free energies of translocating a cyclic Arg(9) peptide into a lipid bilayer along one path that involv ...[more]