Unknown

Dataset Information

0

Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study.


ABSTRACT: BACKGROUND:Axillary hyperpigmentation is a frequent cause of cosmetic consultations in dark-skinned women from tropical areas, including Latin America. Currently, there is no widely accepted treatment for the disorder, but it is usually treated with bleaching agents because it is considered a variant of inflammatory hyperpigmentation. The purpose of this study was to assess the efficacy of niacinamide 4% and desonide 0.05% emulsions compared with placebo in the treatment of axillary hyperpigmentation. METHODS:Twenty-four women aged 19-27 years with hyperpigmented axillae (phototype III-V) were randomly assigned to receive the study treatments in the axillary region. Improvement was assessed at baseline, then clinically and by colorimetry 9 weeks later. Quantitative evaluation including melanin, inflammatory infiltrates, NKI/Beteb, CD1a, CD68, and collagen type IV content was performed by histochemistry and immunohistochemistry, assisted by computerized morphometric analysis. RESULTS:Both niacinamide and desonide induced significant colorimetric improvement compared with placebo; however, desonide showed a better depigmenting effect than niacinamide. A good to excellent response was achieved in 24% of cases for niacinamide, 30% for desonide, and 6% for placebo. We observed a marked disruption of the basal membrane in axillary hyperpigmentation and an inflammatory infiltrate that improved after treatment. Decreased pigmentation in the desonide-treated axillae was associated with recovery of disruption at the basal membrane. CONCLUSION:Niacinamide and desonide showed depigmenting properties in women with axillary hyperpigmentation. These findings may be explained by their antimelanogenic and anti-inflammatory properties, respectively.

SUBMITTER: Castanedo-Cazares JP 

PROVIDER: S-EPMC3552481 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

altmetric image

Publications

Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study.

Castanedo-Cazares Juan Pablo JP   Lárraga-Piñones Gabryela G   Ehnis-Pérez Adriana A   Fuentes-Ahumada Cornelia C   Oros-Ovalle Cuauhtemoc C   Smoller Bruce R BR   Torres-Álvarez Bertha B  

Clinical, cosmetic and investigational dermatology 20130114


<h4>Background</h4>Axillary hyperpigmentation is a frequent cause of cosmetic consultations in dark-skinned women from tropical areas, including Latin America. Currently, there is no widely accepted treatment for the disorder, but it is usually treated with bleaching agents because it is considered a variant of inflammatory hyperpigmentation. The purpose of this study was to assess the efficacy of niacinamide 4% and desonide 0.05% emulsions compared with placebo in the treatment of axillary hype  ...[more]

Similar Datasets

| S-EPMC2440276 | biostudies-literature
| S-EPMC9293301 | biostudies-literature
| S-EPMC7601781 | biostudies-literature
| S-EPMC6625242 | biostudies-literature
| S-EPMC4077042 | biostudies-other
2016-07-15 | E-GEOD-76003 | biostudies-arrayexpress
| S-EPMC7059286 | biostudies-literature
2016-07-15 | GSE76003 | GEO
| S-EPMC5947135 | biostudies-other
2019-12-13 | GSE132648 | GEO