Controlling the function of DNA nanostructures with specific trigger sequences.
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ABSTRACT:
SUBMITTER: Deborggraeve S
PROVIDER: S-EPMC3552611 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Controlling the function of DNA nanostructures with specific trigger sequences.
Deborggraeve Stijn S Dai Jian Yuan JY Xiao Yi Y Soh Hyongsok Tom HT
Chemical communications (Cambridge, England) 20121128 4
We report a hybridization-based switching mechanism with single-base specificity that can be readily integrated with functional DNA nanostructures. As an exemplar, we have developed a switchable DNAzyme (SDZ) that only becomes activated in the presence of a perfectly matched trigger sequence and operates effectively at room temperature. ...[more]
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