Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.
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ABSTRACT:
SUBMITTER: Bertrand FE
PROVIDER: S-EPMC3552917 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.
Bertrand Fred E FE Angus C William CW Partis William J WJ Sigounas George G
Cell cycle (Georgetown, Tex.) 20121003 23
A hallmark of cancer is reactivation/alteration of pathways that control cellular differentiation during developmental processes. Evidence indicates that WNT, Notch, BMP and Hedgehog pathways have a role in normal epithelial cell differentiation, and that alterations in these pathways accompany establishment of the tumorigenic state. Interestingly, there is recent evidence that these pathways are intertwined at the molecular level, and these nodes of intersection may provide opportunities for ef ...[more]
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