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Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.


ABSTRACT: A hallmark of cancer is reactivation/alteration of pathways that control cellular differentiation during developmental processes. Evidence indicates that WNT, Notch, BMP and Hedgehog pathways have a role in normal epithelial cell differentiation, and that alterations in these pathways accompany establishment of the tumorigenic state. Interestingly, there is recent evidence that these pathways are intertwined at the molecular level, and these nodes of intersection may provide opportunities for effective targeted therapies. This review will highlight the role of the WNT, Notch, BMP and Hedgehog pathways in colon cancer.

SUBMITTER: Bertrand FE 

PROVIDER: S-EPMC3552917 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.

Bertrand Fred E FE   Angus C William CW   Partis William J WJ   Sigounas George G  

Cell cycle (Georgetown, Tex.) 20121003 23


A hallmark of cancer is reactivation/alteration of pathways that control cellular differentiation during developmental processes. Evidence indicates that WNT, Notch, BMP and Hedgehog pathways have a role in normal epithelial cell differentiation, and that alterations in these pathways accompany establishment of the tumorigenic state. Interestingly, there is recent evidence that these pathways are intertwined at the molecular level, and these nodes of intersection may provide opportunities for ef  ...[more]

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