Ontology highlight
ABSTRACT:
SUBMITTER: Stone K
PROVIDER: S-EPMC3553080 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Stone Katie K Woods Emily E Szmania Susann M SM Stephens Owen W OW Garg Tarun K TK Barlogie Bart B Shaughnessy John D JD Hall Brett B Reddy Manjula M Hoering Antje A Hansen Emily E van Rhee Frits F
PloS one 20130123 1
Multicentric Castleman Disease is largely driven by increased signaling in the pathway for the plasma cell growth factor interleukin-6. We hypothesized that interleukin-6/interleukin-6 receptor/gp130 polymorphisms contribute to increased interleukin-6 and/or other components of the interleukin-6 signaling pathway in HIV-negative Castleman Disease patients. The study group was composed of 58 patients and 50 healthy donors of a similar racial/ethnic profile. Of seven polymorphisms chosen for analy ...[more]