Dataset Information

Total serum cholesterol and cancer incidence in the Metabolic syndrome and Cancer Project (Me-Can).

ABSTRACT:

Objective

To investigate the association between total serum cholesterol (TSC) and cancer incidence in the Metabolic syndrome and Cancer project (Me-Can).

Methods

Me-Can consists of seven cohorts from Norway, Austria, and Sweden including 289,273 male and 288,057 female participants prospectively followed up for cancer incidence (n?=?38,978) with a mean follow-up of 11.7 years. Cox regression models with age as the underlying time metric were used to estimate hazard ratios (HR) and their 95% confidence intervals (CI) for quintiles of cholesterol levels and per 1 mmol/l, adjusting for age at first measurement, body mass index (BMI), and smoking status. Estimates were corrected for regression dilution bias. Furthermore, we performed lag time analyses, excluding different times of follow-up, in order to check for reverse causation.

Results

In men, compared with the 1st quintile, TSC concentrations in the 5th quintile were borderline significantly associated with decreasing risk of total cancer (HR?=?0.94; 95%CI: 0.88, 1.00). Significant inverse associations were observed for cancers of the liver/intrahepatic bile duct (HR?=?0.14; 95%CI: 0.07, 0.29), pancreas cancer (HR?=?0.52, 95% CI: 0.33, 0.81), non-melanoma of skin (HR?=?0.67; 95%CI: 0.46, 0.95), and cancers of the lymph-/hematopoietic tissue (HR?=?0.68, 95%CI: 0.54, 0.87). In women, hazard ratios for the 5th quintile were associated with decreasing risk of total cancer (HR?=?0.86, 95%CI: 0.79, 0.93) and for cancers of the gallbladder (HR?=?0.23, 95%CI: 0.08, 0.62), breast (HR?=?0.70, 95%CI: 0.61, 0.81), melanoma of skin (HR?=?0.61, 95%CI: 0.42, 0.88), and cancers of the lymph-/hematopoietic tissue (HR?=?0.61, 95%CI: 0.44, 0.83).

Conclusion

TSC was negatively associated with risk of cancer overall in females and risk of cancer at several sites in both males and females. In lag time analyses some associations persisted, suggesting that for these cancer sites reverse causation did not apply.

SUBMITTER: Strohmaier S

PROVIDER: S-EPMC3553083 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Total serum cholesterol and cancer incidence in the Metabolic syndrome and Cancer Project (Me-Can).

Strohmaier Susanne S Edlinger Michael M Manjer Jonas J Stocks Tanja T Bjørge Tone T Borena Wegene W Häggström Christel C Engeland Anders A Nagel Gabriele G Almquist Martin M Selmer Randi R Tretli Steinar S Concin Hans H Hallmans Göran G Jonsson Håkan H Stattin Pär P Ulmer Hanno H

PloS one 20130123 1

<h4>Objective</h4>To investigate the association between total serum cholesterol (TSC) and cancer incidence in the Metabolic syndrome and Cancer project (Me-Can).<h4>Methods</h4>Me-Can consists of seven cohorts from Norway, Austria, and Sweden including 289,273 male and 288,057 female participants prospectively followed up for cancer incidence (n = 38,978) with a mean follow-up of 11.7 years. Cox regression models with age as the underlying time metric were used to estimate hazard ratios (HR) an ...[more]

PMID: 23372693

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Project description:AimsThe total cholesterol (TC)/high-density lipoprotein (HDL) cholesterol ratio may carry additional information not available in more commonly used single cholesterol measures. Analysis of discordance between lipid parameters might help assess the impact of such additional information on the risk of atherosclerotic cardiovascular disease. We aimed to investigate the role of the TC/HDL-cholesterol ratio in determining atherosclerotic cardiovascular disease risk when discordant with low-density lipoprotein (LDL) cholesterol and non-HDL-cholesterol.MethodsWe studied 14,403 Atherosclerosis Risk in Communities (ARIC) study participants who were free of atherosclerotic cardiovascular disease at baseline. TC/HDL-cholesterol discordance with LDL-cholesterol (estimated by the novel Martin/Hopkins method) and non-HDL-cholesterol was assessed at five visits and determined by being at or above the median for each lipid parameter. We constructed Cox proportional hazard models to estimate the risk for incident atherosclerotic cardiovascular disease events associated with each lipid concordance/discordance category using a time-varying approach.ResultsMean age of participants was 54.1 years, 56% women and 25% black. There were 2634 atherosclerotic cardiovascular disease events over a median (interquartile range) follow-up of 24.2 (16.0-25.4) years. Among individuals with LDL-cholesterol and non-HDL-cholesterol less than the median, 26% and 21% had discordant TC/HDL-cholesterol at or above the median, respectively. These individuals had a 24% (hazard ratio (HR) 1.24, 95% confidence interval (CI) 1.09, 1.41) and 29% (HR 1.29, 95% CI 1.13, 1.46) greater risk of incident atherosclerotic cardiovascular disease, respectively, compared to those with TC/HDL-cholesterol less than the median after multivariable adjustment. In individuals with diabetes with LDL-cholesterol or non-HDL-cholesterol less than the median, discordant TC/HDL-cholesterol at or above the median was more prevalent at 48% and 38%, respectively.ConclusionClinically significant discordance exists between TC/HDL-cholesterol, available from the standard lipid profile, and the routinely used non-HDL-cholesterol and LDL-cholesterol. Such discordance may help inform atherosclerotic cardiovascular disease risk management, particularly in individuals with diabetes in whom discordance is more common.

Dataset Information

Total serum cholesterol and cancer incidence in the Metabolic syndrome and Cancer Project (Me-Can).

Objective

Methods

Results

Conclusion

Publications

Total serum cholesterol and cancer incidence in the Metabolic syndrome and Cancer Project (Me-Can).

Similar Datasets

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