Ontology highlight
ABSTRACT:
SUBMITTER: Gao X
PROVIDER: S-EPMC3553500 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Gao Xiaofei X Wang Xiaogang X Pham Thanh H TH Feuerbacher Leigh Ann LA Lubos Marie-Luise ML Huang Minzhao M Olsen Rachel R Mushegian Arcady A Slawson Chad C Hardwidge Philip R PR
Cell host & microbe 20130116 1
Modulation of NF-κB-dependent responses is critical to the success of attaching/effacing (A/E) human pathogenic E. coli (EPEC and EHEC) and the natural mouse pathogen Citrobacter rodentium. NleB, a highly conserved type III secretion system effector of A/E pathogens, suppresses NF-κB activation, but the underlying mechanisms are unknown. We identified the mammalian glycolysis enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH) as an NleB-interacting protein. Further, we discovered that GAPDH ...[more]