Ontology highlight
ABSTRACT:
SUBMITTER: Thurlow LR
PROVIDER: S-EPMC3553549 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Thurlow Lance R LR Joshi Gauri S GS Clark Justin R JR Spontak Jeffrey S JS Neely Crystal J CJ Maile Robert R Richardson Anthony R AR
Cell host & microbe 20130116 1
The USA300 community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) lineage causes the majority of skin and soft tissue infections (SSTIs) and is highly associated with the carriage of the arginine catabolic mobile element (ACME). However, the contribution of ACME to USA300's success in SSTIs is not completely understood. We show that the constitutive ACME-encoded arginine-deiminase system (Arc) allows USA300 to thrive in acidic environments that mimic human skin. Consequently, ...[more]