Integrative systems biology approaches in asthma pharmacogenomics.
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ABSTRACT:
SUBMITTER: Dahlin A
PROVIDER: S-EPMC3553555 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Publications
Integrative systems biology approaches in asthma pharmacogenomics.
Dahlin Amber A Tantisira Kelan G KG
Pharmacogenomics 20120901 12
In order to improve therapeutic outcomes, there is a tremendous need to identify patients who are likely to respond to a given asthma treatment. Pharmacogenomic studies have explained a portion of the variability in drug response and provided an increasing list of candidate genes and SNPs. However, as phenotypic variation arises from a network of complex interactions among genetic and environmental factors, rather than individual genes or SNPs, a multidisciplinary, systems-level approach is requ ...[more]
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