Ontology highlight
ABSTRACT:
SUBMITTER: Theys K
PROVIDER: S-EPMC3553726 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20121126 2
Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specif ...[more]