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HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir.

ABSTRACT: Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways.

SUBMITTER: Theys K 

PROVIDER: S-EPMC3553726 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir.

Theys K K   Vercauteren J J   Snoeck J J   Zazzi M M   Camacho R J RJ   Torti C C   Schülter E E   Clotet B B   Sönnerborg A A   De Luca A A   Grossman Z Z   Struck D D   Vandamme A-M AM   Vandamme A-M AM   Abecasis A B AB  

Antimicrobial agents and chemotherapy 20121126 2

Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specif  ...[more]

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