Ontology highlight
ABSTRACT:
SUBMITTER: Pegu P
PROVIDER: S-EPMC3554145 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Pegu Poonam P Vaccari Monica M Gordon Shari S Keele Brandon F BF Doster Melvin M Guan Yongjun Y Ferrari Guido G Pal Ranajit R Ferrari Maria Grazia MG Whitney Stephen S Hudacik Lauren L Billings Erik E Rao Mangala M Montefiori David D Tomaras Georgia G Alam S Munir SM Fenizia Claudio C Lifson Jeffrey D JD Stablein Donald D Tartaglia Jim J Michael Nelson N Kim Jerome J Venzon David D Franchini Genoveffa G
Journal of virology 20121121 3
The recombinant canarypox vector, ALVAC-HIV, together with human immunodeficiency virus (HIV) gp120 envelope glycoprotein, has protected 31.2% of Thai individuals from HIV acquisition in the RV144 HIV vaccine trial. This outcome was unexpected, given the limited ability of the vaccine components to induce CD8(+) T-cell responses or broadly neutralizing antibodies. We vaccinated macaques with an immunization regimen intended to mimic the RV144 trial and exposed them intrarectally to a dose of the ...[more]