Differential requirements for HIV-1 Vif-mediated APOBEC3G degradation and RUNX1-mediated transcription by core binding factor beta.
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ABSTRACT:
SUBMITTER: Du J
PROVIDER: S-EPMC3554157 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Differential requirements for HIV-1 Vif-mediated APOBEC3G degradation and RUNX1-mediated transcription by core binding factor beta.
Du Juan J Zhao Ke K Rui Yajuan Y Li Peng P Zhou Xiaohong X Zhang Wenyan W Yu Xiao-Fang XF
Journal of virology 20121121 3
Core binding factor beta (CBFβ), a transcription regulator through RUNX binding, was recently reported critical for Vif function. Here, we mapped the primary functional domain important for Vif function to amino acids 15 to 126 of CBFβ. We also revealed that different lengths and regions are required for CBFβ to assist Vif or RUNX. The important interaction domains that are uniquely required for Vif but not RUNX function represent novel targets for the development of HIV inhibitors. ...[more]
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