Serum levels of the adipokine progranulin depend on renal function.

ABSTRACT:

Objective

Progranulin has recently been introduced as a novel adipokine inducing insulin resistance and obesity. In the current study, we investigated renal elimination, as well as association of the adipokine with markers of the metabolic syndrome.

Research design and methods

Progranulin serum levels were quantified by enzyme-linked immunosorbent assay and correlated to anthropometric and biochemical parameters of renal function and glucose and lipid metabolism, as well as inflammation, in 532 patients with stages 1-5 of chronic kidney disease (CKD).

Results

Median serum progranulin levels adjusted for age, sex, and BMI were significantly different between CKD stages with highest values detectable in stage 5 (stage 1, 58.3 µg/L; stage 2, 63.0 µg/L; stage 3, 65.4 µg/L

SUBMITTER: Richter J 

PROVIDER: S-EPMC3554312 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature