Dataset Information

Efficacy and safety of Suanzaoren decoction for primary insomnia: a systematic review of randomized controlled trials.

ABSTRACT:

Background

Insomnia is a widespread human health problem, but there currently are the limitations of conventional therapies available. Suanzaoren decoction (SZRD) is a well known classic Chinese herbal prescription for insomnia and has been treating people's insomnia for more than thousand years. The objective of this study was to evaluate the efficacy and safety of SZRD for insomnia.

Methods

A systematic literature search was performed for 6 databases up to July of 2012 to identify randomized control trials (RCTs) involving SZRD for insomniac patients. The methodological quality of RCTs was assessed independently using the Cochrane Handbook for Systematic Reviews of Interventions.

Results

Twelve RCTs with total of 1376 adult participants were identified. The methodological quality of all included trials are no more than 3/8 score. Majority of the RCTs concluded that SZRD was more significantly effective than benzodiazepines for treating insomnia. Despite these positive outcomes, there were many methodological shortcomings in the studies reviewed, including insufficient information about randomization generation and absence of allocation concealment, lack of blinding and no placebo control, absence of intention-to-treat analysis and lack of follow-ups, selective publishing and reporting, and small number of sample sizes. A number of clinical heterogeneity such as diagnosis, intervention, control, and outcome measures were also reviewed. Only 3 trials reported adverse events, whereas the other 9 trials did not provide the safety information.

Conclusions

Despite the apparent reported positive findings, there is insufficient evidence to support efficacy of SZRD for insomnia due to the poor methodological quality and the small number of trials of the included studies. SZRD seems generally safe, but is insufficient evidence to make conclusions on the safety because fewer studies reported the adverse events. Further large sample-size and well-designed RCTs are needed.

SUBMITTER: Xie CL

PROVIDER: S-EPMC3554563 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Publications

Efficacy and safety of Suanzaoren decoction for primary insomnia: a systematic review of randomized controlled trials.

Xie Cheng-long CL Gu Yong Y Wang Wen-Wen WW Lu Lin L Fu Deng-lei DL Liu Ai-ju AJ Li Hui-qin HQ Li Ji-huang JH Lin Yan Y Tang Wen-jie WJ Zheng Guo-qing GQ

BMC complementary and alternative medicine 20130122

<h4>Background</h4>Insomnia is a widespread human health problem, but there currently are the limitations of conventional therapies available. Suanzaoren decoction (SZRD) is a well known classic Chinese herbal prescription for insomnia and has been treating people's insomnia for more than thousand years. The objective of this study was to evaluate the efficacy and safety of SZRD for insomnia.<h4>Methods</h4>A systematic literature search was performed for 6 databases up to July of 2012 to identi ...[more]

PMID: 23336848

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Dataset Information

Efficacy and safety of Suanzaoren decoction for primary insomnia: a systematic review of randomized controlled trials.

Background

Methods

Results

Conclusions

Publications

Efficacy and safety of Suanzaoren decoction for primary insomnia: a systematic review of randomized controlled trials.

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