Ontology highlight
ABSTRACT:
SUBMITTER: Aquilante CL
PROVIDER: S-EPMC3555061 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Aquilante Christina L CL Kosmiski Lisa A LA Bourne David W A DW Bushman Lane R LR Daily Elizabeth B EB Hammond Kyle P KP Hopley Charles W CW Kadam Rajendra S RS Kanack Alexander T AT Kompella Uday B UB Le Merry M Predhomme Julie A JA Rower Joseph E JE Sidhom Maha S MS
British journal of clinical pharmacology 20130101 1
<h4>Aim</h4>The objective of this study was to determine the extent to which the CYP2C8*3 allele influences pharmacokinetic variability in the drug-drug interaction between gemfibrozil (CYP2C8 inhibitor) and pioglitazone (CYP2C8 substrate).<h4>Methods</h4>In this randomized, two phase crossover study, 30 healthy Caucasian subjects were enrolled based on CYP2C8*3 genotype (n = 15, CYP2C8*1/*1; n = 15, CYP2C8*3 carriers). Subjects received a single 15 mg dose of pioglitazone or gemfibrozil 600 mg ...[more]