Association of BMPR1A polymorphism, but not BMP4, with kidney size in full-term newborns.

ABSTRACT:

Background

A correlation between renal mass and nephron number in newborns allows the use of total kidney volume at birth as a surrogate for congenital nephron number. As the bone morphogenetic protein type 4 (BMP4), and its receptor type 1A (BMPR1A, ALK3), play an important role in renal development, we hypothesized that common, functional polymorphisms in their genes might be responsible for variation in kidney size among healthy individuals.

Methods

We recruited 179 healthy full-term newborns born to healthy women. Kidney volume was measured sonographically. Total kidney volume (TKV) was calculated as the sum of left and right kidneys, and normalized for body surface area (TKV/BSA). Genomic DNA was extracted from umbilical cord blood leukocytes, and c.455T > C (rs17563) B

SUBMITTER: Kaczmarczyk M 

PROVIDER: S-EPMC3555310 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature