Prospects for gene transfer for clinical heart failure.
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ABSTRACT:
SUBMITTER: Tang T
PROVIDER: S-EPMC3555515 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Prospects for gene transfer for clinical heart failure.
Tang T T Gao M H MH Hammond H Kirk HK
Gene therapy 20120426 6
Congestive heart failure is an inexorable disease associated with unacceptably high morbidity and mortality. Preclinical results indicate that gene transfer using various proteins is a safe and effective approach for increasing function of the failing heart. In the current review, we provide a summary of cardiac gene transfer in general and summarize findings using adenylyl cyclase 6 as therapeutic gene in the failing heart. We also discuss the potential usefulness of a new treatment for congest ...[more]
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