Ontology highlight
ABSTRACT:
SUBMITTER: Price AJ
PROVIDER: S-EPMC3556581 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Price Amanda J AJ Marzetta Flavia F Lammers Michael M Ylinen Laura M J LM Schaller Torsten T Wilson Sam J SJ Towers Greg J GJ James Leo C LC
Nature structural & molecular biology 20090920 10
TRIMCyps are primate antiretroviral proteins that potently inhibit HIV replication. Here we describe how rhesus macaque TRIMCyp (RhTC) has evolved to target and restrict HIV-2. We show that the ancestral cyclophilin A (CypA) domain of RhTC targets HIV-2 capsid with weak affinity, which is strongly increased in RhTC by two mutations (D66N and R69H) at the expense of HIV-1 binding. These mutations disrupt a constraining intramolecular interaction in CypA, triggering the complete restructuring (>16 ...[more]