Dataset Information

Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks.

ABSTRACT:

Background

Although high doses of ionizing radiation have long been linked to circulatory disease, evidence for an association at lower exposures remains controversial. However, recent analyses suggest excess relative risks at occupational exposure levels.

Objectives

We performed a systematic review and meta-analysis to summarize information on circulatory disease risks associated with moderate- and low-level whole-body ionizing radiation exposures.

Methods

We conducted PubMed/ISI Thomson searches of peer-reviewed papers published since 1990 using the terms "radiation" AND "heart" AND "disease," OR "radiation" AND "stroke," OR "radiation" AND "circulatory" AND "disease." Radiation exposures had to be whole-body, with a cumulative mean dose of < 0.5 Sv, or at a low dose rate (< 10 mSv/day). We estimated population risks of circulatory disease from low-level radiation exposure using excess relative risk estimates from this meta-analysis and current mortality rates for nine major developed countries.

Results

Estimated excess population risks for all circulatory diseases combined ranged from 2.5%/Sv [95% confidence interval (CI): 0.8, 4.2] for France to 8.5%/Sv (95% CI: 4.0, 13.0) for Russia.

Conclusions

Our review supports an association between circulatory disease mortality and low and moderate doses of ionizing radiation. Our analysis was limited by heterogeneity among studies (particularly for noncardiac end points), the possibility of uncontrolled confounding in some occupational groups by lifestyle factors, and higher dose groups (> 0.5 Sv) generally driving the observed trends. If confirmed, our findings suggest that overall radiation-related mortality is about twice that currently estimated based on estimates for cancer end points alone (which range from 4.2% to 5.6%/Sv for these populations).

SUBMITTER: Little MP

PROVIDER: S-EPMC3556625 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Publications

Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks.

Little Mark P MP Azizova Tamara V TV Bazyka Dimitry D Bouffler Simon D SD Cardis Elisabeth E Chekin Sergey S Chumak Vadim V VV Cucinotta Francis A FA de Vathaire Florent F Hall Per P Harrison John D JD Hildebrandt Guido G Ivanov Victor V Kashcheev Valeriy V VV Klymenko Sergiy V SV Kreuzer Michaela M Laurent Olivier O Ozasa Kotaro K Schneider Thierry T Tapio Soile S Taylor Andrew M AM Tzoulaki Ioanna I Vandoolaeghe Wendy L WL Wakeford Richard R Zablotska Lydia B LB Zhang Wei W Lipshultz Steven E SE

Environmental health perspectives 20120622 11

<h4>Background</h4>Although high doses of ionizing radiation have long been linked to circulatory disease, evidence for an association at lower exposures remains controversial. However, recent analyses suggest excess relative risks at occupational exposure levels.<h4>Objectives</h4>We performed a systematic review and meta-analysis to summarize information on circulatory disease risks associated with moderate- and low-level whole-body ionizing radiation exposures.<h4>Methods</h4>We conducted Pub ...[more]

PMID: 22728254

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Dataset Information

Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks.

Background

Objectives

Methods

Results

Conclusions

Publications

Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks.

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