Role of matrix metalloproteinase-8 in atherosclerosis.
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ABSTRACT:
SUBMITTER: Lenglet S
PROVIDER: S-EPMC3556866 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Role of matrix metalloproteinase-8 in atherosclerosis.
Lenglet Sébastien S Mach François F Montecucco Fabrizio F
Mediators of inflammation 20130109
Plaque rupture is the main cause of acute myocardial infarction and stroke. Atherosclerotic plaques have been described to be vulnerable and more prone to rupture when they are characterized by thin, highly inflamed, and collagen-poor fibrous caps and contain elevated levels of proteases, including metalloproteinases (MMPs). Initiation of collagen breakdown in plaques requires interstitial collagenases, a MMP subfamily consisting of MMP-1, MMP-8, and MMP-13. Previous reports demonstrated that MM ...[more]
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