Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons.
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ABSTRACT:
SUBMITTER: Schaeffer M
PROVIDER: S-EPMC3557016 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons.
Schaeffer Marie M Langlet Fanny F Lafont Chrystel C Molino François F Hodson David J DJ Roux Thomas T Lamarque Laurent L Verdié Pascal P Bourrier Emmanuel E Dehouck Bénédicte B Banères Jean-Louis JL Martinez Jean J Méry Pierre-François PF Marie Jacky J Trinquet Eric E Fehrentz Jean-Alain JA Prévot Vincent V Mollard Patrice P
Proceedings of the National Academy of Sciences of the United States of America 20130107 4
To maintain homeostasis, hypothalamic neurons in the arcuate nucleus must dynamically sense and integrate a multitude of peripheral signals. Blood-borne molecules must therefore be able to circumvent the tightly sealed vasculature of the blood-brain barrier to rapidly access their target neurons. However, how information encoded by circulating appetite-modifying hormones is conveyed to central hypothalamic neurons remains largely unexplored. Using in vivo multiphoton microscopy together with flu ...[more]
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