Increased neuronal activity fragments the Golgi complex.
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ABSTRACT:
SUBMITTER: Thayer DA
PROVIDER: S-EPMC3557034 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Increased neuronal activity fragments the Golgi complex.
Thayer Desiree A DA Jan Yuh Nung YN Jan Lily Yeh LY
Proceedings of the National Academy of Sciences of the United States of America 20130107 4
The Golgi complex is essential for many aspects of cellular function, including trafficking and sorting of membrane and secretory proteins and posttranslational modification by glycosylation. We observed reversible fragmentation of the Golgi complex in cultured hippocampal neurons cultured in hyperexcitable conditions. In addition, Golgi fragmentation was found in cultured neurons with hyperactivity due to prolonged blockade of GABA(A)-mediated inhibition or withdrawal of NMDA receptor antagonis ...[more]
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