Ontology highlight
ABSTRACT:
SUBMITTER: Plazas PV
PROVIDER: S-EPMC3557035 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Plazas Paola V PV Nicol Xavier X Spitzer Nicholas C NC
Proceedings of the National Academy of Sciences of the United States of America 20130109 4
The role of electrical activity in axon guidance has been extensively studied in vitro. To better understand its role in the intact nervous system, we imaged intracellular Ca(2+) in zebrafish primary motor neurons (PMN) during axon pathfinding in vivo. We found that PMN generate specific patterns of Ca(2+) spikes at different developmental stages. Spikes arose in the distal axon of PMN and were propagated to the cell body. Suppression of Ca(2+) spiking activity in single PMN led to stereotyped e ...[more]