Ontology highlight
ABSTRACT:
SUBMITTER: Smith BA
PROVIDER: S-EPMC3557048 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Smith Benjamin A BA Daugherty-Clarke Karen K Goode Bruce L BL Gelles Jeff J
Proceedings of the National Academy of Sciences of the United States of America 20130104 4
Actin filament nucleation by actin-related protein (Arp) 2/3 complex is a critical process in cell motility and endocytosis, yet key aspects of its mechanism are unknown due to a lack of real-time observations of Arp2/3 complex through the nucleation process. Triggered by the verprolin homology, central, and acidic (VCA) region of proteins in the Wiskott-Aldrich syndrome protein (WASp) family, Arp2/3 complex produces new (daughter) filaments as branches from the sides of preexisting (mother) fil ...[more]