Ontology highlight
ABSTRACT:
SUBMITTER: Chataway J
PROVIDER: S-EPMC3557363 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Chataway Jeremy J Miller David H DH
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20130101 1
The treatment of relapsing remitting multiple sclerosis has witnessed major progress since the first effective disease modifying treatment, ß-interferon, became available in 1993. One of the most remarkable new treatments has been natalizumab. This review describes the evolution of this humanized anti-α4ß1 monoclonal antibody, from preclinical experimental research through proof-of-concept (phase 1/2) and pivotal (phase 3) clinical trials to the now extensive experience of its use in clinical pr ...[more]