Ontology highlight
ABSTRACT:
SUBMITTER: Atkinson J
PROVIDER: S-EPMC3557495 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Atkinson Jeffrey J Kapralov Alexandr A AA Yanamala Naveena N Tyurina Yulia Y YY Amoscato Andrew A AA Pearce Linda L Peterson Jim J Huang Zhentai Z Jiang Jianfei J Samhan-Arias Alejandro K AK Maeda Akihiro A Feng Weihong W Wasserloos Karla K Belikova Natalia A NA Tyurin Vladimir A VA Wang Hong H Fletcher Jackie J Wang Yongsheng Y Vlasova Irina I II Klein-Seetharaman Judith J Stoyanovsky Detcho A DA Bayîr Hülya H Pitt Bruce R BR Epperly Michael W MW Greenberger Joel S JS Kagan Valerian E VE
Nature communications 20111011
The risk of radionuclide release in terrorist acts or exposure of healthy tissue during radiotherapy demand potent radioprotectants/radiomitigators. Ionizing radiation induces cell death by initiating the selective peroxidation of cardiolipin in mitochondria by the peroxidase activity of its complex with cytochrome c leading to release of haemoprotein into the cytosol and commitment to the apoptotic program. Here we design and synthesize mitochondria-targeted triphenylphosphonium-conjugated imid ...[more]