Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC3557725 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Proteins 20121224 3
Decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) is an essential enzyme in the biosynthesis of cell wall components and a target for development of anti-tuberculosis drugs. We determined the crystal structure of a truncated form of DprE1 from Mycobacterium smegmatis in two crystal forms to up to 2.35 Å resolution. The structure extends from residue 75 to the C-terminus and shares homology with FAD-dependent oxidoreductases of the vanillyl-alcohol oxidase family including the DprE1 homologue ...[more]