Ontology highlight
ABSTRACT:
SUBMITTER: McEver RP
PROVIDER: S-EPMC3557855 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
McEver Rodger P RP Zhu Cheng C
Annual review of cell and developmental biology 20100101
Rolling adhesion on vascular surfaces is the first step in recruiting circulating leukocytes, hematopoietic progenitors, or platelets to specific organs or to sites of infection or injury. Rolling requires the rapid yet balanced formation and dissociation of adhesive bonds in the challenging environment of blood flow. This review explores how structurally distinct adhesion receptors interact through mechanically regulated kinetics with their ligands to meet these challenges. Remarkably, increasi ...[more]