Ontology highlight
ABSTRACT:
SUBMITTER: Collard F
PROVIDER: S-EPMC3557951 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Collard François F Fagan Rebecca L RL Zhang Jianye J Nemet Ina I Palfey Bruce A BA Monnier Vincent M VM
Biochemistry 20110825 37
Fructosamine oxidases (FAOXs) are flavin-containing enzymes that catalyze the oxidative deglycation of low molecular weight fructosamines or Amadori products. The fructosamine substrate is oxidized by the flavin in the reductive half-reaction, and the reduced flavin is then oxidized by molecular oxygen in the oxidative half-reaction. The crystal structure of FAOX-II from Aspergillus fumigatus reveals a unique interaction between Lys53 and the isoalloxazine. The ammonium nitrogen of the lysine is ...[more]