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Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China.


ABSTRACT: Much information is available for the 2009 H1N1 influenza immunity response, but little is known about the antibody change in seasonal influenza before and during the novel influenza A pandemic. In this study, we conducted a cross-sectional serological survey of 4 types of major seasonal influenza in March and September 2009 on a full range of age groups, to investigate seasonal influenza immunity response before and during the outbreak of the sH1N1 influenza in Shenzhen - the largest migration city in China. We found that the 0-5 age group had an increased antibody level for all types of seasonal influenza during the pandemic compared to the pre-outbreak level, in contrast with almost all other age groups, in which the antibody level decreased. Also, distinct from the antibodies of A/H3N2, B/Yamagata and B/Victoria that decreased significantly during the 2009 H1N1 pandemic, the antibody of A/H1N1 showed no statistical difference from the pre-outbreak level. The results suggest that the antibodies against the 2009 sH1N1 cross-reacted with seasonal H1N1. Moreover, the 0-5 age group was under attack by both seasonal and 2009 H1N1 influenza during the pandemic, hence vaccination merely against a new strain of flu might not be enough to protect the youngest group.

SUBMITTER: Wu CL 

PROVIDER: S-EPMC3558489 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China.

Wu Chun-Li CL   Lu Juan J   Wang Maggie Haitian MH   Lv Xing X   Chen Ying Y   Kung Hsiang-fu HF   Zee Benny B   Cheng Xiao-wen XW   He Ming-Liang ML   He Ming-Liang ML  

PloS one 20130129 1


Much information is available for the 2009 H1N1 influenza immunity response, but little is known about the antibody change in seasonal influenza before and during the novel influenza A pandemic. In this study, we conducted a cross-sectional serological survey of 4 types of major seasonal influenza in March and September 2009 on a full range of age groups, to investigate seasonal influenza immunity response before and during the outbreak of the sH1N1 influenza in Shenzhen - the largest migration  ...[more]

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