Ontology highlight
ABSTRACT:
SUBMITTER: Shuster DL
PROVIDER: S-EPMC3558854 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Shuster Diana L DL Bammler Theo K TK Beyer Richard P RP Macdonald James W JW Tsai Jesse M JM Farin Frederico M FM Hebert Mary F MF Thummel Kenneth E KE Mao Qingcheng Q
Drug metabolism and disposition: the biological fate of chemicals 20121121 2
Pregnancy-induced changes in drug pharmacokinetics can be explained by changes in expression of drug-metabolizing enzymes and transporters and/or normal physiology. In this study, we determined gestational age-dependent expression profiles for all metabolic enzyme and transporter genes in the maternal liver, kidney, small intestine, and placenta of pregnant mice by microarray analysis. We specifically examined the expression of genes important for xenobiotic, bile acid, and steroid hormone metab ...[more]