Ontology highlight
ABSTRACT:
SUBMITTER: Fraser JS
PROVIDER: S-EPMC3558917 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Fraser James S JS Gross John D JD Krogan Nevan J NJ
Molecular cell 20130101 2
There is a wide gap between the generation of large-scale biological data sets and more-detailed, structural and mechanistic studies. However, recent studies that explicitly combine data from systems and structural biological approaches are having a profound effect on our ability to predict how mutations and small molecules affect atomic-level mechanisms, disrupt systems-level networks, and ultimately lead to changes in organismal fitness. In fact, we argue that a shared framework for analysis o ...[more]