?Klotho suppresses tumor growth in hepatocellular carcinoma by regulating Akt/GSK-3?/cyclin D1 signaling pathway.
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ABSTRACT:
SUBMITTER: Ye X
PROVIDER: S-EPMC3559476 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
βKlotho suppresses tumor growth in hepatocellular carcinoma by regulating Akt/GSK-3β/cyclin D1 signaling pathway.
Ye Xiaoming X Guo Yu Y Zhang Qi Q Chen Wenjie W Hua Xuefeng X Liu Wei W Yang Yang Y Chen Guihua G
PloS one 20130130 1
βKlotho is a regulator in multiple metabolic processes, while its role in cancer remains unclear. We found the expression of βKlotho was down-regulated in human hepatocellular carcinoma tissues compared with that in paired adjacent non-tumourous liver tissues. Hepatoma cells also showed decreased expression of βKlotho compared with normal hepatocyte cells. Reintroduction of βKlotho into hepatoma cells inhibited their proliferation. The anti-proliferative effect of βKlotho might be linked with G1 ...[more]
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