Ontology highlight
ABSTRACT:
SUBMITTER: Hartleben B
PROVIDER: S-EPMC3559483 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Hartleben Björn B Widmeier Eugen E Suhm Martina M Worthmann Kirstin K Schell Christoph C Helmstädter Martin M Wiech Thorsten T Walz Gerd G Leitges Michael M Schiffer Mario M Huber Tobias B TB
Journal of the American Society of Nephrology : JASN 20130118 2
Precise positioning of the highly complex interdigitating podocyte foot processes is critical to form the normal glomerular filtration barrier, but the molecular programs driving this process are unknown. The protein atypical protein kinase C (aPKC)--a component of the Par complex, which localizes to tight junctions and interacts with slit diaphragm proteins--may play a role. Here, we found that the combined deletion of the aPKCλ/ι and aPKCζ isoforms in podocytes associated with incorrectly posi ...[more]