Ontology highlight
ABSTRACT:
SUBMITTER: Lilja AM
PROVIDER: S-EPMC3559887 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lilja Anna M AM Luo Yu Y Yu Qian-sheng QS Röjdner Jennie J Li Yazhou Y Marini Ann M AM Marutle Amelia A Nordberg Agneta A Greig Nigel H NH
PloS one 20130130 1
Neuronal dysfunction and demise together with a reduction in neurogenesis are cardinal features of Alzheimer's disease (AD) induced by a combination of oxidative stress, toxic amyloid-β peptide (Aβ) and a loss of trophic factor support. Amelioration of these was assessed with the Aβ lowering AD experimental drugs (+)-phenserine and (-)-phenserine in neuronal cultures, and actions in mice were evaluated with (+)-phenserine. Both experimental drugs together with the metabolite N1-norphenserine ind ...[more]