Latent regulatory potential of human-specific repetitive elements.
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ABSTRACT:
SUBMITTER: Ward MC
PROVIDER: S-EPMC3560060 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Latent regulatory potential of human-specific repetitive elements.
Ward Michelle C MC Wilson Michael D MD Barbosa-Morais Nuno L NL Schmidt Dominic D Stark Rory R Pan Qun Q Schwalie Petra C PC Menon Suraj S Lukk Margus M Watt Stephen S Thybert David D Kutter Claudia C Kirschner Kristina K Flicek Paul P Blencowe Benjamin J BJ Odom Duncan T DT
Molecular cell 20121213 2
At least half of the human genome is derived from repetitive elements, which are often lineage specific and silenced by a variety of genetic and epigenetic mechanisms. Using a transchromosomic mouse strain that transmits an almost complete single copy of human chromosome 21 via the female germline, we show that a heterologous regulatory environment can transcriptionally activate transposon-derived human regulatory regions. In the mouse nucleus, hundreds of locations on human chromosome 21 newly ...[more]
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