Ontology highlight
ABSTRACT:
SUBMITTER: Ward MC
PROVIDER: S-EPMC3560060 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Molecular cell 20121213 2
At least half of the human genome is derived from repetitive elements, which are often lineage specific and silenced by a variety of genetic and epigenetic mechanisms. Using a transchromosomic mouse strain that transmits an almost complete single copy of human chromosome 21 via the female germline, we show that a heterologous regulatory environment can transcriptionally activate transposon-derived human regulatory regions. In the mouse nucleus, hundreds of locations on human chromosome 21 newly ...[more]