Ontology highlight
ABSTRACT:
SUBMITTER: Lin H
PROVIDER: S-EPMC3560844 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20121226 1
A practical route to optically pure syn-homocrotylation reagents is described, including highly diastereo- and enantioselective preparation of numerous syn-homocrotyl products, as well as several matched mismatched pairs. NMR experiments suggest that the active homocrotylating species is a cyclopropylcarbinyldichloroborane generated by chloride exchange from the PhBCl(2) activator. Computational studies support the intermediacy of chloroboranes and suggest that homoallyl/homocrotyl transfers occ ...[more]