Ontology highlight
ABSTRACT:
SUBMITTER: Lauc G
PROVIDER: S-EPMC3561084 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lauc Gordan G Huffman Jennifer E JE Pučić Maja M Zgaga Lina L Adamczyk Barbara B Mužinić Ana A Novokmet Mislav M Polašek Ozren O Gornik Olga O Krištić Jasminka J Keser Toma T Vitart Veronique V Scheijen Blanca B Uh Hae-Won HW Molokhia Mariam M Patrick Alan Leslie AL McKeigue Paul P Kolčić Ivana I Lukić Ivan Krešimir IK Swann Olivia O van Leeuwen Frank N FN Ruhaak L Renee LR Houwing-Duistermaat Jeanine J JJ Slagboom P Eline PE Beekman Marian M de Craen Anton J M AJ Deelder André M AM Zeng Qiang Q Wang Wei W Hastie Nicholas D ND Gyllensten Ulf U Wilson James F JF Wuhrer Manfred M Wright Alan F AF Rudd Pauline M PM Hayward Caroline C Aulchenko Yurii Y Campbell Harry H Rudan Igor I
PLoS genetics 20130131 1
Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans using two approaches. After isolating IgG from human plasma, we performed 77 quantitative measurements of N-glycosylation using ultra-performance liquid chromatography (UPLC) in 2,247 individuals from four European discovery populations. In parallel, we measured IgG N-glycans using MALDI-TOF ...[more]