Dataset Information
Genetic variations in the KCNJ5 gene in primary aldosteronism patients from Xinjiang, China.
Ontology highlight
ABSTRACT: Background
Primary aldosteronism (PA) is the most common endocrine form of secondary hypertension, and one of the most common subtypes of sporadic PA is aldosterone-producing adenoma (APA). Recently, two somatic mutations of the KCNJ5 gene were implicated in APA, and two germline mutations were associated with familial hyperaldosteronism III.Objectives
This case-control study was designed to investigate the relationship between genetic variations in the KCNJ5 gene and sporadic PA patients in Xinjiang, China.Methods
Five common single nucleotide polymorphisms (SNPs) of the KCNJ5 gene (rs6590357, rs4937391, rs3740835, rs2604204, and rs11221497) were detected in patients with sporadic PA (n?=?235) and essential hypertension (EH; n=913) by the TaqMan polymerase chain reaction method.Results
The EH group and the PA group showed significant differences in the distributions of genotypes and alleles of rs4937391 and rs2604204 in total and male subjects (P<0.05), as well as rs3740835 in male subjects (P<0.05). However, only the association between the rs2604204 genotype and male sporadic PA remained significant after Bonferroni's correction (P<0.01). Furthermore, logistic regression analysis demonstrated that the CC genotype of rs2604204 was a risk factor for male patients with sporadic PA, after adjusting for age and body mass index (odds ratio=2.228, 95% CI: 1.300-3.819, P=0.004).Conclusion
The genetic variant rs2604204 of KCNJ5 is associated with sporadic PA in Chinese males, suggesting that KCNJ5 may be involved in the pathogenesis of sporadic PA in these particular patients.
SUBMITTER: Li NF
PROVIDER: S-EPMC3561325 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Genetic variations in the KCNJ5 gene in primary aldosteronism patients from Xinjiang, China.
PloS one 20130131 1
<h4>Background</h4>Primary aldosteronism (PA) is the most common endocrine form of secondary hypertension, and one of the most common subtypes of sporadic PA is aldosterone-producing adenoma (APA). Recently, two somatic mutations of the KCNJ5 gene were implicated in APA, and two germline mutations were associated with familial hyperaldosteronism III.<h4>Objectives</h4>This case-control study was designed to investigate the relationship between genetic variations in the KCNJ5 gene and sporadic PA ...[more]
